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High-fat diet reduces the formation of butyrate, but increases succinate, inflammation, liver fat and cholesterol in rats, while dietary fibre counteracts these effects

The KPV dosage guide provides specific protocols for inflammatory conditions

However, the importance of correcting reductive stress is illustrated by the finding that in three Manchester patients with recurrent acute pancreatitis, who were referred after the trials, standard treatment failed: the addition of folate to provide more methyl groups did not help, but a choline supplement did (JM Braganza unpublished)

While some oral and sublingual formulations exist, injection remains the gold standard with the most research support